HSC Biology

HSC Biology practice questions by module

Original questions for every module, with worked explanations and feedback on written answers.

Section I styleMultiple choice, worked or timed
Section II styleShort answers on a stimulus
Written answersRead against the mark points, with your next step

Try 4 questions

Question 1
Grain set in the three groups of wheat florets
GroupTreatmentFlorets that set grain (of 50)
1anthers removed, bagged, pollen of Q added41
2anthers removed, bagged, no pollen added7
3untreated46
In a hypothetical trial, a plant breeder near Wagga Wagga crossed two wheat varieties. In group 1 she removed the anthers from 50 florets of variety P before they shed pollen, covered the florets with paper bags, and later dusted them with pollen from variety Q. Group 2 had the same treatment but was given no pollen. Group 3 was 50 untreated florets of variety P. Which conclusion about the method do the results support?
Question 2
Growth of five colonies on agar containing each antibiotic
ColonyGrows on ampicillinGrows on tetracycline
1nono
2yesyes
3yesno
4yesyes
5yesno
A plasmid carries two resistance genes, one for ampicillin and one for tetracycline. A human gene is inserted into the middle of the tetracycline resistance gene, so that gene no longer works. After bacteria are mixed with the plasmids, five colonies are tested for growth on agar containing each antibiotic. Which colonies carry the recombinant plasmid with the human gene?
Question 3
New cases of malaria in two villages over one year
VillageBed nets usedPopulationNew cases per 1000 people
Village AYes240012
Village BNo210048
A study in two similar villages in South East Asia recorded new cases of malaria over one year. By what percentage was the incidence lower in the village that used insecticide-treated bed nets?
Question 4
Sweat chloride results in one family (hypothetical data)
Family memberHas cystic fibrosisSweat chloride (mmol/L)
Motherno22
Fatherno25
Ava (daughter)yes98
Leo (son)no20
Cystic fibrosis is an autosomal recessive disease. In a hypothetical family, a sweat chloride test above 60 mmol/L indicates cystic fibrosis (see the table). Leo plans a family with a partner whose genetic test shows she is a carrier. What is the probability that their first child will have cystic fibrosis?

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Questions people ask

Are past HSC papers still useful?

Yes, for timing and question style: the syllabus behind them is the one examined in the 2026 and 2027 HSC.